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Ionis Pharmaceuticals, Inc. Common Stock

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Recently reported changes in IONS holdings by institutional investors

Quarterly net insider trading by IONS's directors and management

* Insider trading data parsed from SEC Form 4 filings by Quiver Quantitative. Sign up for the Quiver API for real-time access.

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Key Metrics

Return (1d)

Return (30d)

Return (1Y)

CAGR (Total)

Max Drawdown

Beta

Alpha

Sharpe Ratio

Win Rate

Average Win

Average Loss

Annual Volatility

Annual Std Dev

Information Ratio

Treynor Ratio

Total Trades

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Metrics Definitions
  • Alpha

    Measures a portfolio's risk-adjusted performance against that of its benchmark

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  • Annual Standard Deviation

    Measures how much the portfolio's total return varies from its mean or average.

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  • Annual Volatility

    A statistical measure of the dispersion of returns for the portfolio.

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  • Average Win

    The average return (%) for trades that resulted in a positive return.

  • Average Loss

    The average return (%) for trades that resulted in a negative return.

  • Beta

    A measure of the volatility of the portfolio compared to the market as a whole.

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  • CAGR

    CAGR (Compounded Annual Growth Rate), is the historical annualized rate of return for an investment strategy, throughout the backtest period.

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  • Information Ratio

    A measurement of portfolio returns beyond the returns of its benchmark compared to the volatility of those returns.

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  • Max Drawdown

    the maximum observed loss from a peak to a trough of a portfolio, before a new peak is attained.

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  • Sharpe Ratio

    The Sharpe Ratio is a measure of historical risk-adjusted return, which quantifies the amount of return that an investor received per unit of risk.

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  • Total Trades

    The total number of trades made by this strategy.

  • Treynor Ratio

    Attempts to measure how successful an investment is in providing compensation to investors for taking on investment risk.

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  • Win Rate

    The percentage of total trades that resulted in a positive return.

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Government lobbying spending instances

  • $140,000 Oct 15, 2025 Issue: Health Issues Medicare/Medicaid Taxation/Internal Revenue Code
  • $90,000 Jul 16, 2025 Issue: Health Issues Medicare/Medicaid Taxation/Internal Revenue Code
  • $90,000 Apr 16, 2025 Issue: Health Issues Medicare/Medicaid Taxation/Internal Revenue Code
  • $80,000 Jan 16, 2025 Issue: Health Issues Medicare/Medicaid Taxation/Internal Revenue Code
  • $80,000 Oct 15, 2024 Issue: Taxation/Internal Revenue Code Medicare/Medicaid Health Issues

IONS Estimated quarterly lobbying spending

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U.S. Patents

New IONS patent grants

  • Patent Title: Antisense modulation of ptp1b expression Jun. 23, 2020
  • Patent Title: Modulation of cd40 expression Mar. 26, 2019
  • Patent Title: Compositions and methods for modulating growth hormone receptor expression Jun. 12, 2018
  • Patent Title: Methods and compounds useful in conditions related to repeat expansion May. 22, 2018
  • Patent Title: Methods for modulating c9orf72 expression May. 08, 2018
  • Patent Title: Compositions and methods for modulating apolipoprotein (a) expression May. 01, 2018
  • Patent Title: Compositions and methods for modulating angiopoietin-like 3 expression May. 01, 2018
  • Patent Title: Targeted therapeutic nucleosides and their use Apr. 17, 2018
  • Patent Title: 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations Apr. 17, 2018
  • Patent Title: 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations Apr. 17, 2018
  • Patent Title: Compositions and methods for modulating apolipoprotein c-iii expression Apr. 03, 2018
  • Patent Title: Compositions and methods for modulating hbv expression Apr. 03, 2018
  • Patent Title: Linkage modified oligomeric compounds Mar. 27, 2018
  • Patent Title: Compositions and their uses directed to huntingtin Mar. 20, 2018
  • Patent Title: Oligomeric compounds comprising bicyclic nucleotides and uses thereof Mar. 13, 2018
  • Patent Title: Compounds and methods for modulating apolipoprotein c-iii expression for improving a diabetic profile Mar. 06, 2018
  • Patent Title: Modulation of tmprss6 expression Feb. 06, 2018
  • Patent Title: Methods and compositions for modulating apolipoprotein (a) expression Feb. 06, 2018
  • Patent Title: Methods and compositions for modulating apolipoprotein (a) expression Feb. 06, 2018
  • Patent Title: Cancer treatment Jan. 23, 2018
  • Patent Title: Compositions and methods for modulation of lmna expression Jan. 02, 2018
  • Patent Title: Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals Dec. 19, 2017
  • Patent Title: Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals Dec. 19, 2017
  • Patent Title: Antisense compounds targeting genes associated with fibronectin Nov. 28, 2017
  • Patent Title: 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations Nov. 28, 2017
  • Patent Title: Methods and compositions for modulating alpha-1 antitrypsin expression Oct. 24, 2017
  • Patent Title: Phosphorous-linked oligomeric compounds and their use in gene modulation Sep. 26, 2017
  • Patent Title: Modulation of dystrophia myotonica-protein kinase (dmpk) expression Sep. 19, 2017
  • Patent Title: Method for solution phase detritylation of oligomeric compounds Sep. 12, 2017
  • Patent Title: Gapped oligomeric compounds comprising 5′-modified deoxyribonucleosides in the gap and uses thereof Sep. 05, 2017
  • Patent Title: Oligomeric compounds and methods Aug. 22, 2017
  • Patent Title: Modulation of tmprss6 expression Aug. 08, 2017
  • Patent Title: 5′-end derivatives Aug. 08, 2017
  • Patent Title: Compositions and methods Jul. 25, 2017
  • Patent Title: Compositions comprising alternating 2′-modified nucleosides for use in gene modulation Jul. 18, 2017
  • Patent Title: Method of preparing oligomeric compounds using modified coupling protocols Jul. 11, 2017
  • Patent Title: Competitive modulation of micrornas Jul. 04, 2017
  • Patent Title: Oligomeric compounds comprising bicyclic nucleosides and uses thereof Jul. 04, 2017
  • Patent Title: Bicyclic morpholino compounds and oligomeric compounds prepared therefrom Jun. 27, 2017
  • Patent Title: Modulation of huntingtin expression Jun. 20, 2017
  • Patent Title: Compositions for modulating tau expression Jun. 20, 2017
  • Patent Title: Modulation of hepatitis b virus (hbv) expression Jun. 13, 2017
  • Patent Title: Modulation of prekallikrein (pkk) expression Jun. 06, 2017
  • Patent Title: Modulation of alpha synuclein expression May. 30, 2017
  • Patent Title: Methods for treating hypercholesterolemia May. 16, 2017
  • Patent Title: Compositions and methods for modulating tau expression May. 09, 2017
  • Patent Title: Modulation of apolipoprotein c-iii expression Apr. 18, 2017
  • Patent Title: Compounds and methods for modulating gene expression Apr. 11, 2017
  • Patent Title: Modulation of ube3a-ats expression Apr. 11, 2017
  • Patent Title: Compositions for modulating c9orf72 expression Mar. 28, 2017
Government Contracts

Estimated quarterly amount awarded to IONS from public contracts

IONS News

Recent insights relating to IONS

CNBC Recommendations

Recent picks made for IONS stock on CNBC

Top ETF Holders

ETFs with the largest estimated holdings in IONS

IONS Analyst Ratings

IONS Stock Forecasts
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* Analyst consensus is not financial advice. Please see our data disclaimers .

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Frequently Asked Questions
  • Who owns $IONS stock?

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* These are estimates based on data taken from SEC filings. There may be inaccuracies due to parsing errors, accidental double-counting, incorrect classification of indirectly owned shares, or any other number of issues.

IONS Stock Smart Score

The Quiver Smart Score combines our data on Congress Trading, Lobbying, Insider Trading, CNBC Mentions and more to provide a comprehensive view of the strength of a stock's underlying data.

The Smart Score grades stocks on a scale of 1 (weakest) to 10 (strongest) based on the strength of the underlying data.
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Bull Case vs Bear Case

See concise summaries of analyst reports, presenting both bullish and bearish arguments for a stock.

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About IONS

Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.

  • Address Carlsbad, CA
  • Market Cap 12.3 billion
  • Employees 927
  • Industrial Classification Pharmaceutical Preparations
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